It was in August 2010, The Lancet Infectious Diseases highlighted an article on the emergence of a new antibiotic resistance gene producing an enzyme called New Delhi Metallo-beta-lactamase NDM-1. NDM-1 is being considered as the world's newest superbug, as it is highly resistant to almost all antibiotics including carbapenems.
NDM-1 is a Metallo Beta-Lactamase essentially found in Enterobacteriaceae (principally E. coli and K. pneumoniae).
NDM-1 stands for New Delhi Metallo-beta-lactamase-1, since it was first identified in a Swedish patient of Indian origin, who had been admitted to hospital in New Delhi, India in 2008.
The NDM-1 gene produces an enzyme which makes bacteria resistant to almost all beta-lactams including carbapenems Carbapenems are powerful, broad-spectrum antibiotics, which are often considered to be the last line of defence against multi-resistant strains of bacteria.
The spread of the gene NDM-1 is from one strain of bacteria to another through the exchange of DNA(Transformation).
Links and Publications
1.Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
2.Characterization of a New Metallo-β-Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India
3. .Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia.
NDM-1 is a Metallo Beta-Lactamase essentially found in Enterobacteriaceae (principally E. coli and K. pneumoniae).
NDM-1 stands for New Delhi Metallo-beta-lactamase-1, since it was first identified in a Swedish patient of Indian origin, who had been admitted to hospital in New Delhi, India in 2008.
The NDM-1 gene produces an enzyme which makes bacteria resistant to almost all beta-lactams including carbapenems Carbapenems are powerful, broad-spectrum antibiotics, which are often considered to be the last line of defence against multi-resistant strains of bacteria.
The spread of the gene NDM-1 is from one strain of bacteria to another through the exchange of DNA(Transformation).
Links and Publications
1.Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
2.Characterization of a New Metallo-β-Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India
3. .Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia.