Recombinant DNA Technology:The advent of Recombinant DNA technology has revolutionized the biotech and healthcare sector. The impact of this technology is un-imaginable.
One such product is recombinant human insulin. recombinant human Insulin was the first drug to be licensed, and was developed by Genentech and licensed by Eli Lilly Company.
List of few rDNA technology Products:
- Erythropoietin (EPO)
- Granulocyte colony-stimulating factor (G-CSF)
- alpha-glactosidase A
- alpha-L-iduronidase (rhIDU; laronidase)
- N-acetylgalactosamine-4-sulfatase (rhASB; galsulfase)
- Dornase alfa,
- Tissue plasminogen activator (TPA)
- Interferon (IF) Interferon-beta-1a, Interferon beta-1b
- Insulin-like growth factor 1 (IGF-1)
Polymerase Chain Reaction:PCR or Polymerase chain reaction was developed Kary Mullis in 1983. One of the breakthrough developments in the field of Biotechnology. Development of PCR made genetic identification (Disease diagnosis, Forensic Identification, etc.) a lot more easier than before.
Applications of PCR
- Disease Diagnosis
- Forensic Science
- Amplification & Quantification of DNA
Stem Cells as Regenerative MedicineStem cells are undifferentiated cells which can differentiate to perform specialized functions...There are two different types of stem cells embryonic and adult stem cells.
Stem Cell Therapy has shown to give promising results and there are no other alternatives in some cases, but most of the therapy procedures are in the initial phase of clinical trials and need more study to analyse the results before it can be applied in wide variety of disease conditions.
As there are many controversies involved in it, lot more research need to be done before it can be applied routinely, Stem cell therapy has the potential to revolutionize the way we treat diseases.
Genome Sequencing Technology:Genome Sequencing technology has helped to unlock the secrets of the genetic code. Nowadays complete genome sequencing is possible. By sequencing the complete genome enormous amount of information can be obtained. with the advancement of bioinformatics tools, analysing the genome sequence and comparing with genome of different species are possible and easy.
The way we treat diseases is changing day by day, with the advancement of better therapies and vaccines to boost the healthcare sector. One of the top innovation to be pointed out is the Magic Bullet.
Ehrlich is the scientist who developed the Magic Bullet. The compound which only targets the bacteria which will not harm other cells. Nowadays we can see Monoclonal antibodies which is used in the treat many disease which is to some extent is the modified form of Magic Bullet. Monoclonal antibodies which specifically targets certain type of cells or proteins and initiates cellular immune response to fight against the disease.
List of Some of the FDA approved Therapuetical Monoclonal Antibodies
Adalimumab – for Autoimmune disorders
Bevacizumab – for Colorectal Cancer
Daclizumab – for Transplant Rejection
Ipilimumab - for Melanoma
There are many other Biotechnological Innovations, but i feel these are the five innovations that played major role in revolutionizing biotechnology and healthcare sector.