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Sunday, May 10, 2015

p53 Structure and Function - Cell Cycle Regualtion & Apoptosis




P53 is a tumor suppressor gene, present in eukaryotic cell. Protein encoded by p53 regulates cell cycle and function as tumor suppression, hence it is also known as TP53 or tumor protein.

p53 is referred to as “the guardian of the genome”, as its role in conserving stability by preventing genome mutation. “53” denotes molecular mass of p53 as it runs as 53KDa band on SDS – PAGE.